Metropolitan Police were called at around 8.50pm on Saturday (November 11) to reports of a group of people fighting in a restaurant in Lea Bridge Road.
Officers attended along with paramedics from the London Ambulance Service.
Two teenage boys were found with stab injuries at the scene.
Read More: Man dies after being stabbed inside a car in Newham
A Met Police spokesperson said the victims were rushed to a hospital where their conditions are being assessed.
Officers stopped two men nearby and they were arrested on suspicion of causing grievous bodily harm.
An investigation is underway into the incident. Officers have urged anyone with information to contact the police on 101 quoting CAD 6715/11Nov.
The incident comes just on the day when a 20-year-old was killed in another stabbing incident in Newham.
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