The incident happened in Parkside Road just before 10.50pm yesterday (October 13).
Officers and London Ambulance Service crews attended and found a man injured.
He was pronounced dead at the scene shortly after.
Police enquiries are ongoing to trace and inform his family.
No arrests have been made following the incident.
A spokesperson for Metropolitan Police said: “A murder investigation has been launched following the death of a man in Hounslow.
“Police were called at 22:46hrs on Friday, 13 October, to a report of a man stabbed in Parkside Road, TW3.
“Officers attended along with London Ambulance Service.
“A man, aged in his 40s, was pronounced dead at the scene. Enquires are ongoing to trace and inform his family.
“There has been no arrest at this early stage.
“Any witnesses or anyone with information is asked to call 101 ref CAD 8926/13oct. To remain anonymous please contact Crimestoppers.”
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