The incident happened between junctions 11 and 10 anti-clockwise at around 8.50am today (August 11).
Officers were called to the scene and found a motorcyclist, a woman in her 50s, with serious injuries.
Four out of three lanes are currently closed with one remaining open following the incident.
A spokesperson for Surrey Police said: “We are appealing for witnesses after a collision between a van and a motorcycle on the M25 this morning (11 August).
“The collision took place at around 8.50am, between junctions 11 and 10 anti-clockwise.
“One lane is currently open, with the other three closed.
“The motorcyclist, a woman in her 50s, has been taken to hospital with serious injuries.
“If you witnessed the incident, or have any dashcam, please contact us quoting PR/45230089748 via direct message.
“If you do not wish to leave your name, please call the independent charity Crimestoppers on 0800 555 111.”
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